Cover [Abstract] Entity Registrant Name Entity Central Index Key Document Type Amendment Flag Entity Voluntary Filers Current Fiscal Year End Date Entity Well Known Seasoned Issuer Entity Small Business Entity Shell Company Entity Emerging Growth Company Entity Current Reporting Status Document Period End Date Entity Filer Category Document Fiscal Period Focus Document Fiscal Year Focus Entity Common Stock Shares Outstanding Entity Public Float Document Annual Report Document Transition Report Entity File Number Entity Incorporation State Country Code Entity Tax Identification Number Entity Address Address Line 1 Entity Address Address Line 2 Entity Address City Or Town Entity Address State Or Province Entity Address Postal Zip Code City Area Code Icfr Auditor Attestation Flag Auditor Name Auditor Location Auditor Firm Id Local Phone Number Security 12b Title Trading Symbol Security Exchange Name Entity Interactive Data Current CONSOLIDATED BALANCE SHEETS ASSETS Current assets Cash and cash equivalents Prepaid expenses Other current assets Total current assets [Assets, Current] Right of use asset Property and equipment, net Other assets Total assets [Assets] LIABILITIES AND STOCKHOLDERS' EQUITY Current liabilities Accounts payable Accrued liabilities Note Payable Total current liabilities [Liabilities, Current] Long term liabilities Lease liability Total long term liabilities [Liabilities, Noncurrent] Total liabilities [Liabilities] Stockholders' equity Preferred stock, undesignated, authorized 4,818,654 shares; See Note 8 Series A Preferred stock, par value $.0001, issued 5,181,346 shares; outstanding 210, as of December 31, 2022 and December 31, 2021 Common stock, par value $.0001 per share; authorized 400,000,000 shares; issued and outstanding 2,291,809 as of December 31, 2022 and 1,260,346 as of December 31, 2021, respectively Additional paid-in capital Accumulated deficit Total stockholders' equity [Stockholders' Equity Attributable to Parent] Total liabilities and stockholders' equity [Liabilities and Equity] Statement [Table] Statement [Line Items] Statement Class Of Stock Axis Series A Preferred Stock Preferred Stock, Shares Authorized Common Stock, Par Value Common Stock, Shares Authorized Common Stock, Shares Issued Common Stock, Shares Outstanding Preferred Stock, Par Value Preferred Stock, Shares Issued Preferred Stock, Shares Outstanding CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS Operating expenses General and administrative Research and development Total operating expenses [Operating Expenses] Net operating loss [Operating Income (Loss)] Interest expense Other income, net [Other Nonoperating Income] Net loss [Net Income (Loss) Attributable to Parent] Unrealized gain on marketable securities Total comprehensive loss [Comprehensive Income (Loss), Net of Tax, Attributable to Parent] Net loss per share, basic and diluted Weighted average number of common shares outstanding, basic and diluted CONSOLIDATED STATEMENTS OF STOCKHOLDERS EQUITY Equity Components [Axis] Preferred Stock Common Stock Additional Paid-In Capital Accumulated Other Comprehensive Gain (Loss) Accumulated Deficit Balance, shares [Shares, Issued] Balance, amount Common stock and preferred stock issued for asset acquisition, shares Common stock and preferred stock issued for asset acquisition, amount Common stock issued for convertible preferred stock, shares Common stock issued for convertible preferred stock, amount Pre-funded warrants sold, net of offering costs Compensation on options issued Exercise of warrants, shares Exercise of warrants, amount Exercise of stock options, shares Exercise of stock options, amount Unrealized loss on marketable securities Net loss [Net loss] Pre-funded warrants and warrants sold, net of offering costs Exercise of pre-funded warrants, shares Exercise of pre-funded warrants, amount Balance, shares Balance, amount CONSOLIDATED STATEMENTS OF CASH FLOWS CASH FLOWS FROM OPERATING ACTIVITIES Net Loss Adjustments to reconcile net loss to net cash used in operating activities Depreciation and amortization Interest on debt instrument Amortization of right of use asset Gain on sale of equipment Gain on debt settlement and extinguishment Issuance and vesting of compensatory stock options and warrants Issuance of common stock and preferred stock for asset acquisition Amortization of premium on marketable securities Changes in operating assets and liabilities Accounts receivable, prepaid expenses and other assets Accounts payable and accrued liabilities Long term portion of lease liability Net cash used in operating activities [Net Cash Provided by (Used in) Operating Activities] CASH FLOWS FROM INVESTING ACTIVITIES Sale of marketable securities Purchase of marketable securities [Payments to Acquire Marketable Securities] Purchase of property and equipment [Payments to Acquire Property, Plant, and Equipment] Net cash (used in) provided by investing activities [Net Cash Provided by (Used in) Investing Activities] CASH FLOWS FROM FINANCING ACTIVITIES Proceeds from issuance of warrants and pre-funded warrants, net of issuance costs Proceeds from the issuance of note payable Proceeds from the exercise of warrants Net cash provided by financing activities [Net Cash Provided by (Used in) Financing Activities] Net change in cash and cash equivalents [Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Excluding Exchange Rate Effect] Cash and cash equivalents, beginning of period [Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents] Cash and cash equivalents, end of period Non-cash investing activity Addition to right of use asset obtained from new operating lease liability DESCRIPTION OF BUSINESS DESCRIPTION OF BUSINESS Business Description and Basis of Presentation [Text Block] SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES Significant Accounting Policies [Text Block] BALANCE SHEET COMPONENTS BALANCE SHEET COMPONENTS Supplemental Balance Sheet Disclosures [Text Block] NOTE PAYABLE NOTE PAYABLE Debt Disclosure [Text Block] MERGER MERGER Mergers, Acquisitions and Dispositions Disclosures [Text Block] STOCKHOLDERS EQUITY STOCKHOLDERS' EQUITY COMMITMENTS AND CONTINGENCIES COMMITMENTS AND CONTINGENCIES Commitments and Contingencies Disclosure [Text Block] 401(k) BENEFIT PLAN 401(k) BENEFIT PLAN [401(k) BENEFIT PLAN] INCOME TAXES INCOME TAXES Income Tax Disclosure [Text Block] SUBSEQUENT EVENTS SUBSEQUENT EVENTS Subsequent Events [Text Block] Use Of Estimates Principles Of Consolidation Reverse Stock Split Cash And Cash Equivalents Cash Concentration Risk Liquidity And Capital Resources Deferred financing costs Derivative financial instruments Preclinical Study and Clinical Accruals Property and Equipment, Net Research and Development Costs Income Taxes Stock-Based Compensation Loss Per Share Operating Leases Recent Accounting Pronouncements Fair Value Anti-dilutive Securities Accrued Liabilities Consideration Transferred, Asset Acquired And Liabilities Assumed Schedule of Warrants Options outstanding Options outstanding that have vested and are expected Shares available for grant Schedule of Estimated fair value of options granted Schedule of outstanding stock options Schedule of classification of our lease liabilities Maturities of our operating lease liabilities Schedule of income tax expenses Schedule of tax effects of temporary differences and carry forwards Accumulated Deficit Cash Used In Operating Activities Class Of Warrant Or Right Axis Warrants To Purchase Common Stock[Member] Pre-Funded Warrants To Purchase Common Stock [Member] Options To Purchase Common Stock[Member] Covertible Preferred Shares Outstanding [Member] Anti- Securities Dilutive Cash uninsured amount Federal Deposit Insurance Corporation insurance limits Total current assets [Total current assets] Working capital amount Cash resources Operating Costs Lease Liability Employee Related Total Depreciation expense Note Payable [Notes Payable, Current] PPP loan amount Accrued interest Proceeds from issuance of note payable Interest rate on notes payable Note payable downpayment Monthly installment Fair Value of shares of Common Stock Issued Fair Value of Series B Convertible Preferred Stock issued at closing Total fair value of consideration transferred Tangible assets acquired Accounts payable assumed Total identifiable net assets IPR&D expense recognized Total fair value of consideration Common stock acquired Stock issued for conversion Percentage of preferred stock carries voting rights Series B convertible preferred stock conversion Common stock for conversion Series B stock conversion description Warrants outstanding, beginning [Class of Warrant or Right, Outstanding] Warrants issued Warrants amended and restated Warrants amended and restated [Warrants amended and restated] Warrants outstanding, ending Warrants,Weighted average exercise price, beginning [Class of Warrant or Right, Exercise Price of Warrants or Rights] Weighted average exercise price, issued Weighted average exercise price, amended and restared Weighted average exercise price, amended and restared [Weighted average exercise price, amended and restared] Warrants, weighted average exercise price, ending Share Based Compensation Shares Authorized Under Stock Option Plans By Exercise Price Range Axis Exercise Price One [Member] Exercise Price Two [Member] Exercise Price Three [Member] Exercise Price Four [Member] Number of options outstanding Weighted average remaining contractual life Number of options exercisable and vested Options exercisable and vested weighted average exercise price Plan Name [Axis] Stock Options [Member] Number of option shares vested Weighted average exercise price vested Aggregate intrinsic value vested Weighted average remaining contractual life vested Number of option shares vested and expected to vest Weighted average exercise price vested and expected to vest Aggregate intrinsic value vested and expected to vest Weighted average remaining contractual life vested and expected to vest Grant under 2022 Plan [Member] Options granted, beginning Shares reserved under 2022 Plan Shares rolled over from 2016 Plan Options Granted Options cancelled/forfeited Options granted, ending Number of shares, Options Outstanding, Beginning Number of shares, Options Outstanding, Options granted Number of shares, Options Outstanding, cancelled/forfeited [Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period] Number of shares, Options Outstanding, Ending Weighted average exercise price, option outstanding, Ending Balance [Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price] Weighted average exercise price, Options Options granted Weighted average exercise price, Options cancelled/forfeited Weighted average exercise price, option outstanding, Beginning Balance Grant under 2016 Plan [Member] Number of shares, Options Outstanding, Options granted Number of shares, Options Outstanding, Options exercised [Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period] Warrants,Weighted average exercise price, Options Options granted Warrants,Weighted average exercise price, Options exercised Warrants,Weighted average exercise price, Options cancelled/forfeited Risk-free interest rate (weighted average) Expected volatility (weighted average) Expected term (in years) Expected dividend yield Stock Options 1999 Plan [Member] Number of shares, Options Outstanding, cancelled [Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Expirations in Period] Warrants,Weighted average exercise price, Options cancelled Award Date Axis Award Type [Axis] Related Party [Axis] May 2022 Offering Warrants One Pre-Funded Warrants July 2021 Warrants Series B Preferred Stock July 2021 Offering March 2020 Warrants May 2022 Warrants Five-Year Warrant First Inducement Stock Options Second Inducement Stock Options Inducement Stock Options 1999 Amended Stock Plan 2022 Plan Stock Options 2016 Plan Stock Options 2016 Stock Incentive Plan 2022 Stock Incentive Plan Cheif Medical Officer July 2020 and March 2020 Offerings July 2020 Offering December 2018 Offering July 2020 Warrants Warrants Issued for Services Common Stock, Shares Authorized Common Stock, Par Value Common Stock, Shares Issued [Common Stock, Shares Issued] Common Stock, Shares outstanding Conversion Of Preferred Stock Into Common Stock, Maximum Ownership Limit, Percentage Purchase Price Per Unit Warrants, Outstanding Exercise price Stock Units Issued Proceeds From Issuance Of Common Stock And Pre-funded Warrants, Net Of Issuance Costs Preferred Stock Par Value Preferred Stock Dividend Preferred Stock, Convertible, Conversion Price Preferred Stock Shares Outstanding Preferred Stock, Shares Issued Number Of Securities Called By Warrants Proceeds From Issuance Of Private Placement Stock issued during period, shares Stock issued during period, value Pre-funded Warrants, Fair Value Warrants, Fair Value Warrant to purchase of common stock Warrant to purchase of common stock exercise price Estimated fair value Warrant To Purchase Of Unregistered Common Stock Warrant To Purchase Of Unregistered Common Stock, Value Warrants, Exercise Price Stock Options Description Stock Option Award Granted Stock Options Exercise Term Stock Options Exercise Price Dividend Yield Risk-free interest rate Volatility Factor Rate Expected Life Estimated Fair Value Of The Inducement Stock Option Award Granted Compensation Expense Weighted average fair value Stock options granted fair market value percentage Unvested shares underlying outstanding stock awards Outstanding stock awards General and administrative compensation expense Unrecognized Compensation Costs Weighted average remaining vesting period Stock Options Granted, Vesting Period Number Of Shares Previously Authorized For Issuance Number Of Shares Of Common Stock Authorized For Issuance Preferred Stock, Convertible, Terms Stock Convertible Into An Aggregate Shares Of Common Stock Current Portion Included In Accrued Liabilities Long Term Lease Liability Total [Operating Lease, Liability] 2023 2024 Total Lease Payments Less: Imputed Interest Operating Lease Liability Simdax License Agreement [Member] Annual Lease Term minimum Annual Lease Term maximum Grant paid to canadian authority Grant paid to authority Non refundable up front payment Non-refundable commercialization milestone payment Lease Term Period Optioin to extend description Description Of Lease Contract Annual Base Rent Increased Percentage Of Annual Increase In Rent 401(k) Retirement Savings Plan [Member] Contribution Term Period Contributions expense Contribution percentage rate U.S. federal tax benefit at statutory rate [Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount] State income tax benefit, net of federal benefit [Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Amount] Stock compensation Other nondeductible, including IPR and D expense Change in state tax rate Federal and state net operating loss adjustments Other, including effect of tax rate brackets Change in realizability of IPR and D Change in valuation allowance Income-tax expense (benefit) Deferred Tax Assets Net operating loss carryforwards Accruals and others Capital loss carryoforwards Valuation allowance [Deferred Tax Assets, Valuation Allowance] Net deferred tax assets Deferred Tax Liabilities Other liabilities [Deferred Tax Liabilities, Other] Net deferred tax liabilities Income Tax Authority Axis Federal [Member] State [Member] Income tax rate Description of income taxes Valuation allowance, decrease Operating Loss Carryforwards Net operating losses Remaining operating losses carryforward Subsequent Event Type [Axis] Related Party Transaction [Axis] Subsequent Events [Member] Roth Capital Partners, LLC [Member] Stockholders' equity [Stockholders' Equity, Other] Minimum Requirement of Nasdaq Capital Market Public Offering for net proceeds Cash Common stock, minimum closing price per share Lease termination agreement amount paid Lease termination date Warrants to purchase shares of common stock Sale of common stock shares Sale of common stock, price per share Issuance of pre fund warrant shares Issuance of pre fund warrant shares, offering price per share Common warrant, pre-funded warrant per share price Gross proceeds from common stock warrants Estimated net proceeds from public offering after deduction of placement agent fees and estimated offering expenses payable Custom Element. Custom Element. Custom Element. Custom Element. Custom Element. Custom Element. Custom Element.